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27. Arruda-Olson AM, Mahoney DW, Nehra A, Leckel M, Pellikka PA "Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial." JAMA 287 (2002): 719-25Things You Didn't Know About Cialis buy cialis generic Usual Adult Dose for Benign Prostatic Hyperplasia:

Creatinine clearance less than 30 mL/min or on hemodialysis: CIALIS for once daily use is not recommended [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)].

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Results of these studies showed that Levitra did not alter the total treadmill exercise time compared to placebo (10 mg Levitra vs. placebo: 433±109 and 426±105 seconds, respectively; 20 mg Levitra vs. placebo: 414±114 and 411±124 seconds, respectively). The total time to angina was not altered by Levitra when compared to placebo (10 mg Levitra vs. placebo: 291±123 and 292±110 seconds; 20 mg Levitra vs. placebo: 354±137 and 347±143 seconds, respectively). The total time to 1 mm or greater ST-segment depression was similar to placebo in both the 10 mg and the 20 mg Levitra groups (10 mg Levitra vs. placebo: 380±108 and 334±108 seconds; 20 mg Levitra vs. placebo: 364±101 and 366±105 seconds, respectively).The effect of 10 mg and 80 mg vardenafil on QT interval was evaluated in a single-dose, double-blind, randomized, placebo- and active-controlled (moxifloxacin 400 mg) crossover study in 59 healthy males (81% White, 12% Black, 7% Hispanic) aged 45-60 years. The QT interval was measured at one hour post dose because this time point approximates the average time of peak vardenafil concentration. The 80 mg dose of Levitra (four times the highest recommended dose) was chosen because this dose yields plasma concentrations covering those observed upon co-administration of a low-dose of Levitra (5 mg) and 600 mg BID of ritonavir. Of the CYP3A4 inhibitors that have been studied, ritonavir causes the most significant drug-drug interaction with vardenafil. Table 6 summarizes the effect on mean uncorrected QT and mean corrected QT interval (QTc) with different methods of correction (Fridericia and a linear individual correction method) at one hour post-dose. No single correction method is known to be more valid than the other. In this study, the mean increase in heart rate associated with a 10 mg dose of Levitra compared to placebo was 5 beats/minute and with an 80 mg dose of Levitra the mean increase was 6 beats/minute.

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Drug substanceThe placebo-subtracted mean maximal decreases in systolic blood pressure over a 12-hour period after dosing in the placebo-controlled portion of the study (part C) are shown in Table 6 and Figure 3.No tome sildenafil si usted también esta usando un nitrato para el dolor de pecho o problemas del corazón. Estos incluyen nitroglycerin, isosorbide dinitrate, y isosorbide mononitrate. Los nitratos también se encuentran en algunas de las drogas de diversión, como amyl nitrate o nitritos ("poppers"). Tomar sildenafil con un nitrato puede causar una disminución repentina y grave en la presión arterial.

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