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Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5OH3PO4H2O and a molecular weight of 523.32. The structural formula is:

Why Diclofenac Sodium EC should not be prescribed Diclofenac Sodium EC should not be used by people in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema) Diclofenac Sodium EC should not be used if you have a history of bleeding from the stomach or intestines. Diclofenac Sodium EC should not be used if suspect or have a history of Peptic ulcer. Diclofenac Sodium EC should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, s using Diclofenac Sodium EC and inform your doctor or pharmacist immediately. Possible Diclofenac Sodium EC Side effects More common side effects of Diclofenac Sodium EC may include: abdominal pain or cramps, constipation, diarrhea, headache, indigestion, nausea Less common side effects of Diclofenac Sodium EC may include: abdominal bleeding, abdominal swelling, dizziness, fluid retention, gas, itching, peptic ulcers, rash, ringing in the ears Rare side effects of Diclofenac Sodium EC may include: anaphylaxis (severe allergic reaction), anemia, anxiety, appetite change, asthma, black stools, blood disorders, bloody diarrhea, blurred vision, changes in taste, colitis, congestive heart failure, convulsions, decrease in white blood cells, decreased urine production, depression, double vision, drowsiness, dry mouth and mucous membranes, hair loss, hearing loss, hepatitis, high blood pressure, hives, inability to sleep, inflammation of the colon, inflammation of mouth, inflammation of the pancreas, irritability, kidney failure, liver disease, low blood pressure, nosebleed, red or purple skin discoloration and itching, sensitivity to light, skin eruptions and inflammation, scaling or peeling, sores in the gullet, Stevens-Johnson syndrome (a severe form of skin eruption), swelling of eyelids, lips, and tongue, swelling of the throat due to fluid retention, vague feeling of illness, vision changes, vomiting, yellow eyes and skin

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secretion of milk, seizures (convulsions), and Side effects of moderate or severe intensity included dizziness (up to 9%), headache (up to 8%), impaired concentration (up to 5%), and somnolence (up to 2%).

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Active tuberculosis, including reactivation of latent tuberculosis. Patients with tuberculosis have frequently presented with disseminated or extrapulmonary disease. Patients should be tested for latent tuberculosis before Enbrel use and during therapy. Treatment for latent infection should be initiated prior to Enbrel use.

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